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Ubiquitin and proteasome pathways

TopicLeading institutions, researchers & key papers

Ubiquitin and proteasome pathways is a topic indexed in PICO Portal from OpenAlex.

What is known about Ubiquitin and proteasome pathways?

PICO Portalrecord summary

This cluster of papers focuses on the Ubiquitin-Proteasome Proteolytic Pathway, exploring mechanisms of protein degradation, regulation of E3 Ubiquitin Ligases, roles of Deubiquitinating Enzymes, and the impact of SUMOylation. It also delves into the development of proteasome inhibitors for cancer therapy and the involvement of this pathway in NF-?B activation.

How many works does Ubiquitin and proteasome pathways have?

PICO Portalindexed works

Ubiquitin and proteasome pathways has 266 works in the PICO Portal index. The count is the OpenAlex total, not the number of papers listed on this page.

What is the OpenAlex record for Ubiquitin and proteasome pathways?

PICO Portalopenalex

The OpenAlex for Ubiquitin and proteasome pathways is on the source record.

What are the most-cited papers on Ubiquitin and proteasome pathways?

PICO Portalmost cited works
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro
Jeffrey Winston, Peter R. Strack, Peggy Beer‐Romero, Chia‐Yu Chu, Stephen J. Elledge, J. Wade Harper
Genes & Development. 1999950 CitationsOPEN ACCESS
How the ubiquitin–proteasome system controls transcription
Masafumi Muratani, William P. Tansey
Nature Reviews Molecular Cell Biology. 2003805 Citations
The role of ubiquitination in tumorigenesis and targeted drug discovery
Lu Deng, Tong Meng, Lei Chen, Wenyi Wei, Ping Wang
Signal Transduction and Targeted Therapy. 2020780 CitationsOPEN ACCESS
SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, Daming Gao, Alan Tseng, Richard S. Maser, Bo Zhai, Lixin Wan, Alejandro Gutiérrez, Alan W. Lau, Yonghong Xiao, Amanda L. Christie, Jon C. Aster, Jeffrey Settleman, Steven P. Gygi, Andrew L. Kung, Thomas Look, Keiichi I. Nakayama, Ronald A. DePinho, Wenyi Wei
Nature. 2011634 CitationsOPEN ACCESS
Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer
Erik Kupperman, Edmund C. Lee, Yueying Cao, Bret Bannerman, Michael Fitzgerald, Allison Berger, Jie Yu, Yang Yu, Paul Hales, Frank J. Bruzzese, Jane Liu, Jonathan L. Blank, Khristofer Garcia, Christopher Tsu, Larry Dick, Paul Fleming, Li Yu, Mark Manfredi, Mark Rolfe, Joe Bolen
Cancer Research. 2010496 Citations

Where is Ubiquitin and proteasome pathways research published, and who funds it?

PICO Portalvenues & funding sources

TOP FUNDERS

National Science Foundation—
NIH—
Wellcome Trust—
European Research Council—
Funder breakdown is a member featureSign up free to unlock

How much of the research on Ubiquitin and proteasome pathways is open access?

PICO Portalopen access share
53%OPEN ACCESS
Gold
20%
Green
7%
Hybrid
0%
Bronze
27%
Closed
47%

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