PICO Portalanswers from OpenAlex
Cancer therapeutics and mechanisms
TopicLeading institutions, researchers & key papers
Cancer therapeutics and mechanisms is a topic indexed in PICO Portal from OpenAlex.
What is known about Cancer therapeutics and mechanisms?
PICO Portalrecord summary
This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes.
How many works does Cancer therapeutics and mechanisms have?
PICO Portalindexed works
Cancer therapeutics and mechanisms has 174 works in the PICO Portal index. The count is the OpenAlex total, not the number of papers listed on this page.
What is the OpenAlex record for Cancer therapeutics and mechanisms?
PICO Portalopenalex
The OpenAlex for Cancer therapeutics and mechanisms is on the source record.
What are the most-cited papers on Cancer therapeutics and mechanisms?
PICO Portalmost cited works
Topoisomerase I inhibitors: camptothecins and beyond
Yves Pommier
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
Yves Pommier, Elisabetta Leo, Hongliang Zhang, Christophe Marchand
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Yves Pommier, Yilun Sun, Shar-yin N. Huang, John L. Nitiss
Drugging Topoisomerases: Lessons and Challenges
Yves Pommier
Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation
Noritaka Tanaka, Jessica J. Lin, Chendi Li, Meagan B. Ryan, Junbing Zhang, Lesli A. Kiedrowski, Alexa Michel, Mohammed U. Syed, Katerina A. Fella, Mustafa Sakhi, Islam Baiev, Dejan Juric, Justin F. Gainor, Samuel J. Klempner, Jochen K. Lennerz, Giulia Siravegna, Liron Bar‐Peled, Aaron N. Hata, Rebecca S. Heist, Ryan B. Corcoran
Where is Cancer therapeutics and mechanisms research published, and who funds it?
PICO Portalvenues & funding sources
TOP JOURNALS
TOP FUNDERS
National Science Foundation—
NIH—
Wellcome Trust—
European Research Council—
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How much of the research on Cancer therapeutics and mechanisms is open access?
PICO Portalopen access share
67%OPEN ACCESS