# Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

**Type:** Papers  
**Canonical URL:** https://picoportal.org/library/papers/synthetic-lethality-by-targeting-ezh2-methyltransferase-activity-in-arid1a/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Benjamin G. Bitler,Katherine M. Aird,Azat Garipov,Hua Li,Michael Amatangelo,Andrew V. Kossenkov,D. Schultz,Qin Liu,Ie‐Ming Shih,José R. Conejo-García,David W. Speicher,Rugang Zhang |
| Citations | 686 |
| DOI | 10.1038/nm.3799 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | true |
| OA Status | green |
| OA URL | https://www.ncbi.nlm.nih.gov/pmc/articles/4352133 |
| OpenAlex ID | https://openalex.org/W2048122601 |
| PMID | 25686104 |
| Type | article |
| Year | 2015 |

## Paper authors

- [David W. Speicher](https://picoportal.org/library/researchers/david-w-speicher/)
- [José R. Conejo-García](https://picoportal.org/library/researchers/jose-r-conejo-garcia/)
- [D. Schultz](https://picoportal.org/library/researchers/d-schultz/)
- [Hua Li](https://picoportal.org/library/researchers/hua-li-3/)
- [Qin Liu](https://picoportal.org/library/researchers/qin-liu/)
- [Ie‐Ming Shih](https://picoportal.org/library/researchers/ie-ming-shih/)
- [Andrew V. Kossenkov](https://picoportal.org/library/researchers/andrew-v-kossenkov/)

## Paper journal

- [Nature Medicine](https://picoportal.org/library/journals/nature-medicine/)

## Paper primary topic

- [Chromatin Remodeling and Cancer](https://picoportal.org/library/topics/chromatin-remodeling-and-cancer/)

## Paper topics

- [Chromatin Remodeling and Cancer](https://picoportal.org/library/topics/chromatin-remodeling-and-cancer/)
- [Cancer Mechanisms and Therapy](https://picoportal.org/library/topics/cancer-mechanisms-and-therapy/)
- [Protein Degradation and Inhibitors](https://picoportal.org/library/topics/protein-degradation-and-inhibitors/)

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Source: PICO Portal — public research metadata, principally OpenAlex. See https://picoportal.org/library/sources/ for provenance and https://picoportal.org/library/methodology/ for what these figures mean.