# Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models

**Type:** Papers  
**Canonical URL:** https://picoportal.org/library/papers/synthetic-lethal-interaction-of-combined-bcl-xl-and-mek-inhibition-promotes/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Ryan B. Corcoran,Katherine A. Cheng,Aaron N. Hata,Anthony C. Faber,Hiromichi Ebi,Erin M. Coffee,Patricia Greninger,Ronald D. Brown,Jason Godfrey,Travis J. Cohoon,Youngchul Song,Eugene Lifshits,Kenneth E. Hung,Toshi Shioda,Dora Dias‐Santagata,Anurag Singh,Jeffrey Settleman,Cyril H. Benes,Mari Mino–Kenudson,Kwok‐Kin Wong,Jeffrey A. Engelman |
| Citations | 383 |
| DOI | 10.1016/j.ccr.2012.11.007 |
| Fields | Biochemistry, Genetics and Molecular Biology,Computer Science |
| Open Access | true |
| OA Status | bronze |
| OA URL | http://www.cell.com/article/S1535610812004874/pdf |
| OpenAlex ID | https://openalex.org/W2009333774 |
| PMID | 23245996 |
| Type | article |
| Year | 2012 |

## Paper authors

- [Ryan B. Corcoran](https://picoportal.org/library/researchers/ryan-b-corcoran/)
- [Mari Mino–Kenudson](https://picoportal.org/library/researchers/mari-mino-kenudson/)
- [Hiromichi Ebi](https://picoportal.org/library/researchers/hiromichi-ebi/)
- [Jeffrey Settleman](https://picoportal.org/library/researchers/jeffrey-settleman/)
- [Toshi Shioda](https://picoportal.org/library/researchers/toshi-shioda/)
- [Dora Dias‐Santagata](https://picoportal.org/library/researchers/dora-dias-santagata/)
- [Kwok‐Kin Wong](https://picoportal.org/library/researchers/kwok-kin-wong/)
- [Cyril H. Benes](https://picoportal.org/library/researchers/cyril-h-benes/)
- [Jeffrey A. Engelman](https://picoportal.org/library/researchers/jeffrey-a-engelman/)

## Paper journal

- [Cancer Cell](https://picoportal.org/library/journals/cancer-cell/)

## Paper primary topic

- [Retinoids in leukemia and cellular processes](https://picoportal.org/library/topics/retinoids-in-leukemia-and-cellular-processes/)

## Paper topics

- [Retinoids in leukemia and cellular processes](https://picoportal.org/library/topics/retinoids-in-leukemia-and-cellular-processes/)
- [Computational Drug Discovery Methods](https://picoportal.org/library/topics/computational-drug-discovery-methods/)
- [Melanoma and MAPK Pathways](https://picoportal.org/library/topics/melanoma-and-mapk-pathways/)

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Source: PICO Portal — public research metadata, principally OpenAlex. See https://picoportal.org/library/sources/ for provenance and https://picoportal.org/library/methodology/ for what these figures mean.