# Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

**Type:** Papers  
**Canonical URL:** https://picoportal.org/library/papers/mutations-in-smad3-cause-a-syndromic-form-of-aortic-aneurysms-and-dissections/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Ingrid M.B.H. van de Laar,Rogier A. Oldenburg,Gerard Pals,Jolien W. Roos‐Hesselink,Bianca M. de Graaf,Judith M.A. Verhagen,Yvonne M. Hoedemaekers,Rob Willemsen,Lies‐Anne Severijnen,Hanka Venselaar,Gert Vriend,Peter M. T. Pattynama,Margriet Collée,Daniëlle Majoor‐Krakauer,Don Poldermans,Ingrid M.E. Frohn-Mulder,Dimitra Micha,Janneke Timmermans,Yvonne Hilhorst‐Hofstee,Sita Bierma‐Zeinstra,Patrick J. Willems,Johan M. Kros,E.H. Oei,Ben A. Oostra,Marja W. Wessels,Aida M. Bertoli‐Avella |
| Citations | 677 |
| DOI | 10.1038/ng.744 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | false |
| OA Status | closed |
| OpenAlex ID | https://openalex.org/W2125633197 |
| PMID | 21217753 |
| Type | article |
| Year | 2011 |

## Paper authors

- [Gert Vriend](https://picoportal.org/library/researchers/gert-vriend/)
- [Jolien W. Roos‐Hesselink](https://picoportal.org/library/researchers/jolien-w-roos-hesselink/)
- [Sita Bierma‐Zeinstra](https://picoportal.org/library/researchers/sita-bierma-zeinstra/)
- [Patrick J. Willems](https://picoportal.org/library/researchers/patrick-j-willems/)
- [Rob Willemsen](https://picoportal.org/library/researchers/rob-willemsen/)
- [Johan M. Kros](https://picoportal.org/library/researchers/johan-m-kros/)
- [Don Poldermans](https://picoportal.org/library/researchers/don-poldermans/)
- [Ben A. Oostra](https://picoportal.org/library/researchers/ben-a-oostra-2/)

## Paper journal

- [Nature Genetics](https://picoportal.org/library/journals/nature-genetics/)

## Paper primary topic

- [Connective tissue disorders research](https://picoportal.org/library/topics/connective-tissue-disorders-research/)

## Paper topics

- [Connective tissue disorders research](https://picoportal.org/library/topics/connective-tissue-disorders-research/)
- [Aortic Disease and Treatment Approaches](https://picoportal.org/library/topics/aortic-disease-and-treatment-approaches/)
- [Aortic aneurysm repair treatments](https://picoportal.org/library/topics/aortic-aneurysm-repair-treatments/)

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Source: PICO Portal — public research metadata, principally OpenAlex. See https://picoportal.org/library/sources/ for provenance and https://picoportal.org/library/methodology/ for what these figures mean.