# <i>BRCA</i> Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

**Type:** Papers  
**Canonical URL:** https://picoportal.org/library/papers/i-brca-i-reversion-mutations-in-circulating-tumor-dna-predict-primary-and/

## Facts

| Field | Value |
| --- | --- |
| Author Names | Kevin Lin,Maria I. Harrell,Amit M. Oza,Ana Oaknin,Isabelle Ray‐Coquard,Anna V. Tinker,Elena Helman,Marc R. Radke,Carmen Say,Lan-Thanh Vo,Elaina Mann,Jeffrey D. Isaacson,Lara Maloney,David M. O’Malley,Setsuko K. Chambers,Scott H. Kaufmann,Clare L. Scott,Gottfried E. Konecny,Robert L. Coleman,James Sun,Heidi Giordano,James D. Brenton,Thomas C. Harding,Iain A. McNeish,Elizabeth M. Swisher |
| Citations | 439 |
| DOI | 10.1158/2159-8290.cd-18-0715 |
| Fields | Biochemistry, Genetics and Molecular Biology,Medicine |
| Open Access | false |
| OA Status | closed |
| OpenAlex ID | https://openalex.org/W2901506506 |
| PMID | 30425037 |
| Type | article |
| Year | 2018 |

## Paper authors

Showing 10 of 13.

- [Kevin Lin](https://picoportal.org/library/researchers/kevin-lin/)
- [James D. Brenton](https://picoportal.org/library/researchers/james-d-brenton/)
- [Scott H. Kaufmann](https://picoportal.org/library/researchers/scott-h-kaufmann/)
- [Gottfried E. Konecny](https://picoportal.org/library/researchers/gottfried-e-konecny/)
- [Ana Oaknin](https://picoportal.org/library/researchers/ana-oaknin/)
- [Amit M. Oza](https://picoportal.org/library/researchers/amit-m-oza/)
- [Isabelle Ray‐Coquard](https://picoportal.org/library/researchers/isabelle-ray-coquard/)
- [Clare L. Scott](https://picoportal.org/library/researchers/clare-l-scott/)
- [Robert L. Coleman](https://picoportal.org/library/researchers/robert-l-coleman/)
- [Elena Helman](https://picoportal.org/library/researchers/elena-helman/)

## Paper journal

- [Cancer Discovery](https://picoportal.org/library/journals/cancer-discovery/)

## Paper primary topic

- [PARP inhibition in cancer therapy](https://picoportal.org/library/topics/parp-inhibition-in-cancer-therapy/)

## Paper topics

- [PARP inhibition in cancer therapy](https://picoportal.org/library/topics/parp-inhibition-in-cancer-therapy/)
- [Ovarian cancer diagnosis and treatment](https://picoportal.org/library/topics/ovarian-cancer-diagnosis-and-treatment/)
- [BRCA gene mutations in cancer](https://picoportal.org/library/topics/brca-gene-mutations-in-cancer/)

---
Source: PICO Portal — public research metadata, principally OpenAlex. See https://picoportal.org/library/sources/ for provenance and https://picoportal.org/library/methodology/ for what these figures mean.